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Fulcrum Therapeutics

3.85

-0.0200-0.52%

Post-market: 3.850.00000.00%16:20 EDT

Volume:1.63M

Turnover:6.30M

Market Cap:293.74M

PE:-3.18

High:3.90

Open:3.88

Low:3.83

Close:3.87

52wk High:15.74

52wk Low:2.83

Shares:76.30M

Float Shares:63.49M

Volume Ratio:1.16

T/O Rate:2.57%

Dividend:- -

Dividend Rate:- -

EPS(TTM):-1.2104

EPS(LYR):-1.1819

ROE:-32.38%

ROA:-19.59%

PB:0.95

PE(LYR):-3.26

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Overview Company News Filings

This Biotech Stock Plunges 48%. Its Sickle Cell Drug Has 'No Viable Path Forward.' -- Barrons.com

Top Premarket Decliners

MT Newswires Live

BUZZ-U.S. STOCKS ON THE MOVE-Microchip Technology, Marvell Technology, Generac

Fulcrum Therapeutics Cut to Neutral From Buy by HC Wainwright & Co.

HC Wainwright Downgrades Fulcrum Therapeutics to Neutral From Buy, Adjusts PT to $3 From $25

MT Newswires Live

Fulcrum plummets 50% after scrapping lead sickle-cell drug on FDA concerns

Fulcrum Therapeutics Inc : H.c. Wainwright Cuts Target Price to $3 From $25

THOMSON REUTERS

Fulcrum Therapeutics downgraded to Market Perform from Outperform at Leerink

Fulcrum Therapeutics Shares Slide 49.4% to $3.25 Premarket After Co Scraps Sickle Cell Drug Development

THOMSON REUTERS

Piper double downgrades Fulcrum after sickle cell development stopped

U.S. RESEARCH ROUNDUP-Edgewise Therapeutics, IBM, Rubrik

Fulcrum Therapeutics Inc : Truist Securities Cuts to Hold From Buy; Cuts Target Price to $4 From $17

THOMSON REUTERS

Fulcrum Therapeutics downgraded to Underweight from Overweight at Piper Sandler

Fulcrum Therapeutics downgraded to Hold from Buy at Stifel

BUZZ-Fulcrum Therapeutics falls after scrapping sickle cell drug development

Fulcrum discontinues pociredir program in SCD, initiates strategic review

Fulcrum Therapeutics Ends Sickle Cell Disease Drug Development, Starts Strategic Review

Fulcrum Therapeutics Announces Discontinuation of Pociredir Program in Sickle Cell Disease and Initiation of Strategic Review

THOMSON REUTERS

Fulcrum Therapeutics - to Explore Merger, Acquisition, or Other Strategic Transactions

THOMSON REUTERS

Fulcrum Therapeutics - Initiates Efforts to Reduce Operating Expenses and Preserve Capital

THOMSON REUTERS

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Biotech Stock Plunges 48%. Its Sickle Cell Drug Has 'No Viable Path Forward.' -- Barrons.com","url":"https://stock-news.laohu8.com/highlight/detail?id=2640910163","media":"Dow Jones","labels":["productRelease"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2640910163?lang=en_us&edition=fundamental","pubTime":"2026-06-02 19:53","pubTimestamp":1780401180,"startTime":"0","endTime":"0","summary":"With no products on the market, Fulcrum Therapeutics was striving to commercialize its experimental drug for sickle cell disease. Those plans have come to a grinding halt.The Cambridge, Mass.-based biopharmaceutical company said Tuesday that it has discontinued its pociredir program for the treatment of sickle cell disease and launched \"a comprehensive review of strategic alternatives to maximize stockholder value.\". Shares plunged nearly 49% to $3.30 in the premarket session, on pace for their largest same-day drop since September 2024, according to Dow Jones Market Data. Futures tracking the benchmark S&P 500 were down 0.2%.On May 28, Fulcrum received meeting minutes from the Food and Drug Administration that raised questions about the drug's risks and benefits. Regulators pointed to \"an unexpectedly high rate\" of new cancers occurring in patients taking tazemetostat, another investigational therapy that was pulled from the market in March.The decision \"left no viable regulatory path","market":"fut","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://dowjonesnews.com/newdjn/logon.aspx?AL=N","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-2","news_top_title":null,"news_tag":"productRelease","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["BK4581","BK4585","BK4588","FULC","BK4007","XBI"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2640891087","title":"Top Premarket Decliners","url":"https://stock-news.laohu8.com/highlight/detail?id=2640891087","media":"MT Newswires Live","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2640891087?lang=en_us&edition=fundamental","pubTime":"2026-06-02 19:36","pubTimestamp":1780400180,"startTime":"0","endTime":"0","summary":"Fulcrum Therapeutics  shares were down 49% in Tuesday premarket activity after multiple analysts downgraded the stock and sharply lowered their price targets.Jianzhi Education Technology  stock was down 43%, after a 325% gain in Monday's session.Abivax  stock was down 30% after the company's phase 3 maintenance trial evaluating obefazimod in ulcerative colitis met its primary endpoint and key secondary endpoints, though malignancy cases reported during the trial weighed on the results.Hitek Global  shares were down 21%, following the previous session's 350% gain.Quhuo  shares were down 20%, extending losses from the previous 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mean price target of $9.22, according to analysts polled by FactSet.(MT Newswires covers equity, commodity and economic research from majo","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":["rate"],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.mtnewswires.com/","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"mtnewswires_news","symbols":["FULC"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2640491289","title":"Fulcrum plummets 50% after scrapping lead sickle-cell drug on FDA concerns","url":"https://stock-news.laohu8.com/highlight/detail?id=2640491289","media":"Reuters","labels":["productRelease"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2640491289?lang=en_us&edition=fundamental","pubTime":"2026-06-02 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In 2024, Pfizer PFE.N withdrew its approved therapy Oxbryta and stopped related studies over safety concerns.Fulcrum said no new safety concerns had emerged in clinical trials and that the drug had shown increases in fetal hemoglobin, which can help reduce disease severity in sickle-cell patients.  ","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20260602:nL4N42A0RL:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-2","news_top_title":null,"news_tag":"productRelease","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["FULC","BK4007"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2640191484","title":"Fulcrum Therapeutics Inc : H.c. 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with Ipsen's IPN.PA drug called Tazverik which was recently withdrawn from the global market     ** Co has initiated efforts to significantly reduce its operating expenses and preserve capital** As of March 31, 2026, Fulcrum had $333.3 million in cash, cash equivalents, and marketable securities** FULC down 43% Y","market":"fut","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20260601:nL4N4291MS:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-2","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["BK4007","FULC"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2640962682","title":"Fulcrum discontinues pociredir program in SCD, initiates strategic 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The stock closed down 7.2% at $6.42, down 43% this year.FDA officials brought up a high rate of blood cancers associated with Tazverik, a cancer medication which targets a similar group of genes as pociredir. 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