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SPYRE THERAPEUTICS INC

86.47

-2.0350-2.30%

Volume:336.89K

Turnover:29.70M

Market Cap:7.62B

PE:-43.02

High:90.18

Open:88.05

Low:85.00

Close:88.50

52wk High:110.18

52wk Low:14.51

Shares:88.17M

Float Shares:80.98M

Volume Ratio:0.81

T/O Rate:0.42%

Dividend:- -

Dividend Rate:- -

EPS(TTM):-2.0100

EPS(LYR):-1.9755

ROE:-22.98%

ROA:-19.81%

PB:7.99

PE(LYR):-43.77

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Overview Company News Filings

Press Release: Spyre Therapeutics Reports First Quarter 2026 Financial Results and Provides Corporate Update

Spyre Therapeutics CFO Scott Burrows disposes 12,500 shares worth $892,125

Spyre Therapeutics CMO Sheldon Sloan disposes of common shares worth $3.69 million

Spyre CEO Cameron Turtle sells $1.05 million common shares

Spyre Therapeutics grants stock options for 20,800 shares under inducement plan

Spyre Therapeutics Announces Grants of Inducement Awards

Analysts Conflicted on These Healthcare Names: Teladoc (TDOC), Spyre Therapeutics (SYRE) and Regeneron (REGN)

How Investors May Respond To Spyre Therapeutics (SYRE) Upsized Equity Raise After Positive SPY001 Phase 2 Data

Simply Wall St.

Wall Street Analysts Are Bullish on Top Healthcare Picks

Analysts Offer Insights on Healthcare Companies: Spyre Therapeutics (SYRE) and Revolution Medicines (RVMD)

Analysts Are Bullish on These Healthcare Stocks: Praxis Precision Medicines (PRAX), Spyre Therapeutics (SYRE)

Spyre Therapeutics closes follow-on offering, raises USD 463.5 million

BUZZ-U.S. STOCKS ON THE MOVE-Nike, PNC Financia, OSI Systems

BUZZ-Spyre Therapeutics gains after boosted $403 mln stock sale

Spyre Therapeutics Prices Upsized $403 Million Share Offering

MT Newswires Live

BRIEF-Spyre Therapeutics Announces Pricing Of Upsized $403 Million Public Offering Of Common Stock

Spyre Therapeutics Inc - Prices Public Offering of 6.5 Mln Shares at $62.00 per Share

THOMSON REUTERS

Spyre Therapeutics Announces Pricing of Upsized $403.0 Million Public Offering of Common Stock

THOMSON REUTERS

Assessing Spyre Therapeutics (SYRE) Valuation After Recent Share Price Momentum And Premium P/B Multiple

Simply Wall St.

Stock Track | Spyre Therapeutics Soars 6.99% in Pre-Market on Multiple Analyst Target Price Hikes

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Release: Spyre Therapeutics Reports First Quarter 2026 Financial Results and Provides Corporate Update","url":"https://stock-news.laohu8.com/highlight/detail?id=2633910697","media":"Dow Jones","labels":["dataReport"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2633910697?lang=en_us&edition=fundamental","pubTime":"2026-05-05 20:00","pubTimestamp":1777982400,"startTime":"0","endTime":"0","summary":"Announced positive topline induction data from Part A of the Phase 2 SKYLINE trial of SPY001, demonstrating best-in-class efficacy potential and a safety profile consistent with the <ALPHA>4<BETA>7 class. Announced over-enrollment and acceleration of topline readout to the third quarter of 2026 of the rheumatoid arthritis  sub-study of the Phase 2 SKYWAY basket trial. Remain on track for 6 proof-of-concept readouts in 2026 across the SKYLINE and SKYWAY Phase 2 trials. Further strengthened the balance sheet with $463 million gross proceeds from an underwritten public offering of. $1.2 billion in pro forma cash, cash equivalents, and marketable securities as of March 31, 2026, with expected runway into the second half of 2029. The Company is pioneering long-acting antibodies and antibody combinations to redefine the standard of care in IBD and rheumatic diseases. IBD is a chronic condition characterized by inflammation within the gastrointestinal tract, including two main disorders: ulce","market":"fut","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://dowjonesnews.com/newdjn/logon.aspx?AL=N","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"dataReport","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["BK4130","RHI","SYRE","BK4539","LENZ","BK4588","BK4533","LU0054578231.USD","BK4585","BK4139","BK4007"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2632629147","title":"Spyre Therapeutics CFO Scott Burrows disposes 12,500 shares worth $892,125","url":"https://stock-news.laohu8.com/highlight/detail?id=2632629147","media":"Reuters","labels":["shareholding","insiderTrades"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2632629147?lang=en_us&edition=fundamental","pubTime":"2026-05-02 09:36","pubTimestamp":1777685762,"startTime":"0","endTime":"0","summary":"Spyre Therapeutics CFO Scott L. Burrows sold 12,500 common shares on May 1 at USD 71.37.Burrows exercised stock options for 12,500 shares on May 1 at USD 14.5.Directly held common shares totaled 97,994 following transactions.Disclaimer: This news brief was created by Public Technologies  using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. Spyre Therapeutics Inc. published the original content used to generate this news brief via EDGAR, the Electronic Data Gathering, Analysis, and Retrieval system operated by the U.S. Securities and Exchange Commission , on May 01, 2026, and is solely responsible for the information contained therein.","market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20260502:nNDL7Zk1Rz:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-1","news_top_title":null,"news_tag":"shareholding,insiderTrades","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["BK4139","SYRE"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2632262914","title":"Spyre Therapeutics CMO Sheldon Sloan disposes of common shares worth $3.69 million","url":"https://stock-news.laohu8.com/highlight/detail?id=2632262914","media":"Reuters","labels":["shareholding","insiderTrades"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2632262914?lang=en_us&edition=fundamental","pubTime":"2026-05-02 09:35","pubTimestamp":1777685720,"startTime":"0","endTime":"0","summary":"Spyre Therapeutics Chief Medical Officer Sheldon Sloan exercised options for 78,333 shares at USD 27.46 on May 1, 2026.Sloan sold 78,333 shares on May 1, 2026 in multiple trades at weighted average prices ranging from USD 69.53 to USD 75.37.Stock options beneficially owned totaled 321,667 following transactions.Disclaimer: This news brief was created by Public Technologies  using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. Spyre Therapeutics Inc. published the original content used to generate this news brief via EDGAR, the Electronic Data Gathering, Analysis, and Retrieval system operated by the U.S. Securities and Exchange Commission , on May 01, 2026, and is solely responsible for the information contained therein.","market":"fut","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20260502:nNDLbpCsmW:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-1","news_top_title":"Spyre Therapeutics CMO Sheldon Sloan disposes of common shares worth $3.69 million","news_tag":"shareholding,insiderTrades","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["BK4139","SYRE"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2632291556","title":"Spyre CEO Cameron Turtle sells $1.05 million common shares","url":"https://stock-news.laohu8.com/highlight/detail?id=2632291556","media":"Reuters","labels":["shareholding","insiderTrades"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2632291556?lang=en_us&edition=fundamental","pubTime":"2026-05-02 09:34","pubTimestamp":1777685697,"startTime":"0","endTime":"0","summary":"Spyre Therapeutics CEO and director Turtle Cameron sold 15,000 common shares on May 1, 2026.Sales were executed under a Rule 10b5-1 trading plan adopted June 20, 2025.Transaction prices ranged from $69.54 to $74.96 per share.Disclaimer: This news brief was created by Public Technologies  using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. Spyre Therapeutics Inc. published the original content used to generate this news brief via EDGAR, the Electronic Data Gathering, Analysis, and Retrieval system operated by the U.S. Securities and Exchange Commission , on May 01, 2026, and is solely responsible for the information contained therein.","market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20260502:nNDL21tLKJ:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-1","news_top_title":null,"news_tag":"shareholding,insiderTrades","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["BK4139","SYRE"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2632647122","title":"Spyre Therapeutics grants stock options for 20,800 shares under inducement plan","url":"https://stock-news.laohu8.com/highlight/detail?id=2632647122","media":"Reuters","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2632647122?lang=en_us&edition=fundamental","pubTime":"2026-05-02 04:28","pubTimestamp":1777667306,"startTime":"0","endTime":"0","summary":"Spyre Therapeutics granted stock options covering 20,800 common shares to four non-executive employees under its 2018 Equity Inducement Plan.Options carry a 10-year term with an exercise price of $69.42, set at May 1 close.Vesting starts with 25% on first anniversary of each employee’s start date, followed by monthly vesting of remaining balance.","market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20260501:nNDL3YSRgM:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["SG9999014013.SGD","IE00BN0W2W23.USD","LU2095319765.USD","BK4585","BK4588","LU2210150020.SGD","SG9999014005.SGD","LU2210149790.SGD","LU0314104364.USD","IE00B3QW5Z07.USD","IE00BN0W2T93.GBP","NDAQ","SYRE","IE00B64PRP62.GBP","BK4112","SG9999014039.USD","IE00BGHQF748.EUR","SG9999014021.USD","BK4139","IE00BKPKM429.USD","IE00BN0W2V16.EUR"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2632264710","title":"Spyre Therapeutics Announces Grants of Inducement Awards","url":"https://stock-news.laohu8.com/highlight/detail?id=2632264710","media":"GlobeNewswire","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2632264710?lang=en_us&edition=fundamental","pubTime":"2026-05-02 04:28","pubTimestamp":1777667280,"startTime":"0","endTime":"0","summary":"WALTHAM, Mass., May  01, 2026 (GLOBE NEWSWIRE) -- Spyre Therapeutics, Inc. (NASDAQ: SYRE) (the “Company” or “Spyre”), a clinical-stage biotechnology company pioneering long-acting antibodies and antib","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.globenewswire.com/news-release/2026/05/01/3286222/0/en/Spyre-Therapeutics-Announces-Grants-of-Inducement-Awards.html","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["LENZ","SYRE","BK4539","BK4007","BK4139"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2631656750","title":"Analysts Conflicted on These Healthcare Names: Teladoc (TDOC), Spyre Therapeutics (SYRE) and Regeneron (REGN)","url":"https://stock-news.laohu8.com/highlight/detail?id=2631656750","media":"TIPRANKS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2631656750?lang=en_us&edition=fundamental","pubTime":"2026-04-30 22:41","pubTimestamp":1777560068,"startTime":"0","endTime":"0","summary":"Analysts have been eager to weigh in on the Healthcare sector with new ratings on Teladoc (TDOC), Spyre Therapeutics (SYRE) and Regeneron (REGN). T...","market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tipranks_highlight","url":"https://www.tipranks.com/news/blurbs/analysts-conflicted-on-these-healthcare-names-teladoc-tdoc-spyre-therapeutics-syre-and-regeneron-regn-blurbs-news?utm_source=itigerup.com&utm_medium=referral","rn_cache_url":null,"directOrigin":true},"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.tipranks.com/news/blurbs/analysts-conflicted-on-these-healthcare-names-teladoc-tdoc-spyre-therapeutics-syre-and-regeneron-regn-blurbs-news?utm_source=itigerup.com&utm_medium=referral","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"tipranks_highlight","symbols":["BK4581","XLV","BK4588","REGN","HCSG","BK4137","LU2023250504.SGD","LU2237438978.USD","LU0128526141.USD","BK4139","BK4567","SYRE","LABU","BK4585","BK4504","LU2362541273.HKD","LU2089984988.USD","LU0114720955.EUR","LU2106854487.HKD","LU0053666078.USD","BK4534","LU1861559042.SGD","LU0823434740.USD","BK4548","LU0889565916.HKD","TDOC","LU2362540622.SGD","LU1861558580.USD","LU2362541513.USD","LU0029874061.USD","LU1917777945.USD","LU2468319806.SGD","LU0320765992.SGD","LU0823416689.USD","LU0289739699.SGD","BK4167","LU1974910355.USD","LU0882574055.USD","LU0823434583.USD","LU0058720904.USD","XBI","LU0109394709.USD"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2630733118","title":"How 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Street Analysts Are Bullish on Top Healthcare Picks","url":"https://stock-news.laohu8.com/highlight/detail?id=2629034958","media":"TIPRANKS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2629034958?lang=en_us&edition=fundamental","pubTime":"2026-04-21 21:00","pubTimestamp":1776776458,"startTime":"0","endTime":"0","summary":"There’s a lot to be optimistic about in the Healthcare sector as 2 analysts just weighed in on AnaptysBio (ANAB) and Spyre Therapeutics (SYRE) with...","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tipranks_highlight","url":"https://www.tipranks.com/news/blurbs/wall-street-analysts-are-bullish-on-top-healthcare-picks-blurbs-news-110?utm_source=itigerup.com&utm_medium=referral","rn_cache_url":null,"directOrigin":true},"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.tipranks.com/news/blurbs/wall-street-analysts-are-bullish-on-top-healthcare-picks-blurbs-news-110?utm_source=itigerup.com&utm_medium=referral","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"tipranks_highlight","symbols":["XBI","BK4112","BLSG","BK4139","LABU","ANAB","LU0128526141.USD","BK4585","BLSX","LU0029874061.USD","BK4581","BK4588","SYRE","BK4137"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2628132711","title":"Analysts 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It closed at $12.71 a year ago** Of 16 analysts, 10 rate the stock \"strong buy\", 6 \"buy\"; median PT $80, per LSEG 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Therapeutics Prices Upsized $403 Million Share Offering","url":"https://stock-news.laohu8.com/highlight/detail?id=2627409564","media":"MT Newswires Live","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2627409564?lang=en_us&edition=fundamental","pubTime":"2026-04-15 15:21","pubTimestamp":1776237698,"startTime":"0","endTime":"0","summary":"Spyre Therapeutics  said late Tuesday it priced its upsized underwritten public offering of 6.5 million shares at $62 apiece for gross proceeds of about $403 million.The company has also granted underwriters a 30-day option to purchase up to an additional $60.5 million of shares at the offering piece.The offering is expected to close on or about 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